Definition: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
for hematodermic CD4/CD56 neoplasm use LYMPHOMA, NON-HODGKIN
recombinant soluble CD4 [ SK&F 106528,SK&F-106528,sT4 (recombinant),soluble CD4,soluble T4 ] recombinant CD4 with the transmembrane and C-terminal regions deleted; blocks in vitro infectivity of HIV
