Definition: A family of synthetic protein tyrosine kinase inhibitors. They selectively inhibit receptor autophosphorylation and are used to study receptor function.
tyrphostin 47 [ AG 213,AG213,3,4-dihydroxy-alpha-cyanothiocinnamide,3,4-dihydroxy-alpha-cyanothiocinnamide, (E)-isomer,AG-213,RG 50864,RG-50864,RG50864,alpha-cyano-3,4-dihydroxythiocinnamamide,tyrphostin A47,tyrphostin AG-213,tyrphostin AG213,tyrphostin RG50864 ] inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;
