Definition: A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
N(1),N(14)-bis(ethyl)homospermine [ 1,14-bis(ethylamino)-5,10-diazatetradecane,BE-4-4-4,BEHSpm,DEHSPM,N(1),N(14)-diethylhomospermine ] structure given in first source; depletes polyamines and inhibits the growth of tumor cells in tissue culture
