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tirapazamine
under Triazines
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Triazines
Definition
: Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.
do not confuse with TRIAZENES
Other names
Benzotriazines
Substance
CAS Registry & name
Categories
Source
Drugs
*
tirapazamine [ 3-amino-1,2,4-benzothiadi- azine 1,1-dioxide,3-amino-1,2,4-benzotriazine-1,4-dioxide,NSC 130181,SR 4233,SR-4233,Tirazone,WIN 59075,WIN-59075 ]
has high toxicity for hypoxic mammalian cells; structure given in first source
27314-97-2 1,2,4-
Benzotriazin-
3-
amine, 1,4-
dioxide
*Triazines
Pharma Action
Antineoplastic Agents
;
Radiation-Sensitizing Agents
Int J Radiat Oncol Biol Phys 1986;12(7):1239