Definition: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
diamminedichlorodihydroxyplatinum IV [ Pt(IV)(NH3)2Cl2(OH)2,cis-dichlorodihydroxydiamminoplatinum,diamminedichlorodihydroxyplatinum IV, (OC-6-12)-isomer,diamminedichlorodihydroxyplatinum IV, (OC-6-33)-isomer,dichlorodihydroxyammineplatinum,oxoplatin,oxoplatina,oxoplatinum,trans-ODDP ] RN given refers to cpd without isomeric designation; structure given in first source