Definition: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
/chem syn permitted: do not convert to PROSTAGLANDINS, SYNTHETIC; DF: PGX
9-O-methanoprostaglandin I [ 9-O-methano-6 beta-PGI1,9-O-methano-PGI1,9-O-methanoprostaglandin I, 3aR-(3aalpha,5beta,6alpha(1E,3S*),6aalpha)-isomer,9-O-methanoprostaglandin I, 3aS-(3aalpha,5beta,6alpha(1Z,3R*),6aalpha)-isomer,TEI 7165,TEI-7165,isocarbacyclin ] shows weak inhibitory activity in rabbit platelet aggregation induced by ADP; RN given refers to cpd without isomeric designation
