Definition: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 [ 9-deoxy-delta(9), delta(12)-13,14-dihydroprostaglandin D2,9-deoxy-delta(9,12)-13,14-dihydro PGD2,delta(12)-PGJ2 ] delta(12)-PGJ2 is ambiguous shorthand often used for this compound; 15-deoxy-delta(12,14)PGJ2 is also available which has additional double bond at 14 position; PGD2 metabolite in human plasma; RN giv