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brodimoprim

under Trimethoprim
More information in Books or onNLM PubMed
More on Trimethoprim Definition: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.  consider TRIMETHOPRIM RESISTANCE for nonsusceptibility of bacteria    Other names Trimpex; Proloprim Drugs: TRIMPEXTRIMETHOPRIM; PROLOPRIM; TRIMPEX 200; PRIMSOL;
SubstanceCAS Registry & nameCategoriesSourceDrugs*
brodimoprim [ 2,4-diamino-5-(4-bromo-3,5-dimethoxybenzyl)pyrimidine,Ro 10-5970,Ro-10-5970 ]
  inhibits dihydrofolate reductase 		56518-41-3   Trimethoprim/*analogs & derivatives
Pharma Action Anti-Infective Agents; Enzyme Inhibitors; Folic Acid Antagonists 		Acta Pharmacol Toxicol 1982;51(5):446

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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