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transplatin

under Cisplatin
More information in Books or onNLM PubMed
More on Cisplatin Definition: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.      Other names cis-Dichlorodiammineplatinum(II); cis-Diamminedichloroplatinum(II); Platinum Diamminodichloride; cis Platinum; cis Diamminedichloroplatinum; Diamminodichloride, Platinum; cis-Platinum; cis-Diamminedichloroplatinum; Platinol; Platino; Platidiam; Dichlorodiammineplatinum; Biocisplatinum; NSC-119875 Drugs: PLATINOL-AQPLATINOL; CISPLATIN;
SubstanceCAS Registry & nameCategoriesSourceDrugs*
transplatin [ trans-DDP,trans-diamminedichloroplatinum II,trans-dichlorodiammineplatinum II ]
  ineffective as antineoplastic agent 		14913-33-8   *Cisplatin Stereoisomerism
Pharma Action Cross-Linking Reagents 		Biochem Biophys Res Commun 1982;105(3):869

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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