Definition: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
2-amino-7-phosphonoheptanoic acid [ 2-amino-7-phosphoheptanoic acid,2-amino-7-phosphonoheptanoic acid, (+-)-isomer,2-amino-7-phosphonoheptanoic acid, (R)-isomer,D-AP7,2-amino-7-phosphonoheptanoic acid, (S)-isomer,AP-7 compound ] (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation