Definition: A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Other names Nu Sulindac; Nu Pharm Brand of Sulindac; Novo Sundac; MK231; MK 231; Apo Sulin; Sulindal; Nu-Sulindac; Nu-Pharm Brand of Sulindac; Novopharm Brand of Sulindac; Novo-Sundac; Merck Sharp & Dohme Brand of Sulindac; Merck Brand of Sulindac; MK-231; Klinoril; Kendrick Brand of Sulindac; Kenalin; Copal; Clinoril; Chibret
sulindac sulfide [ sulindac sulfide, (E)-isomer,sulindac sulfide, (Z)-isomer,sulindac sulfide, sodium salt ] sulfated analog of indomethacin & inhibitor of prostaglandin synthesis in vitro; RN given refers to cpd without isomeric designation; structure given in first source
