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picrotoxinin

under Picrotoxin
More information in Books or onNLM PubMed
More on Picrotoxin Definition: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.     
SubstanceCAS Registry & nameCategoriesSourceDrugs*
picrotoxinin [ picrotoxinine ]
  toxic component of picrotoxin; structure; noncompetitive antagonist of ionotropic GABA-A receptors 		17617-45-7 (1aR-(1a alpha,2a beta,3 beta,6 beta,6a beta,8aS*,8b beta,9R*))-hexahydro-2a-hydroxy-8b-methyl-9-(1-methylethenyl)-3,6-methano-8H-1,5,7-trioxa cyclopenta(ij)cycloprop(a)azulene-4,8(3H)-dione  Picrotoxin/*analogs & derivatives
Pharma Action GABA-A Receptor Antagonists 		Nature 282(5744):298;1980

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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