Definition: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
leukocyte endogenous mediator [ endogenous pyrogen,leukocyte pyrogen ] low MW protein (10,000-30,000) preparation, induces changes typical of those seen in acute phase of inflammation; prepared from rabbit polymorphonuclear leukocytes