4-nitrobenzylthioinosine (definition)

encyclopedia of medical concepts

4-nitrobenzylthioinosine

under Thioinosine

More information in Books or on

Definition: Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. It has been used similarly to MERCAPTOPURINE in the treatment of leukemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p503)

Other names 6-Mercaptopurine Riboside; Ribosyl 6 mercaptopurine; Riboside, 6-Mercaptopurine; 6 Mercaptopurine Riboside; Ribosyl-6-mercaptopurine; NSC-4911

Substance	CAS Registry & name	Categories	Source	Drugs*
4-nitrobenzylthioinosine [ 4-NBMI,4-nitrobenzyl-6-mercaptoinosine,4-nitrobenzylmercaptopurine ribonucleoside,6-((4-nitrobenzyl)mercapto)purine ribonucleoside,6-((4-nitrobenzyl)thio)-9-beta-D-ribofuranosylpurine,NBMPR,NBT cpd,NBTI,nitrobenzyl-6-thioinosine ] inhibitor of nucleoside transport; acts on ENT1	38048-32-7	Thioinosine/analogs & derivatives Pharma Action* Affinity Labels	Ann NY Acad Sci 255:402;1975; Arch Int Pharmacodyn Ther 238(2):257;1979; Biochem Pharmacol 27(8):1303;1978; Can J Biochem 50(7):839;1972; Biochim Biophys Acta 1980;597(1):183; Biochim Biophys Acta 455:817;1976; Biochim Biophys Acta 467:51;1977; Cancer Res 1979;39(9):3607; Cancer Res 35(5):1187;1975; Cancer Res 39(4):1245;1979; Cancer Res 39(6):2216;1979; Exp Cell Res 105(2):427;1977; Exp Cell Res 119(2):393;1979; J Cell Physiol 92(2):185;1977; J Membr Biol 39(2/3):133;1978; J Membr Biol 42(3):247;1978; J Physiol 284:96P;1978; Mol Pharmacol 13(5):883;1977; Mol Pharmacol 13(6):1014;1977; Mol Pharmacol 1979;16(3):900

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link

Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor

We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy